Aspirin Enteric Coated Tablets 100mg "Nichiiko" antiplatelet agent
 
Contents
It is used as a basic drug for antiplatelet therapy. Aspirin, the active ingredient, is a very old drug that has been used for many years as an antipyretic and analgesic. Recently, it has often been used to treat thrombus and embolism by applying its antiplatelet effect at low doses. Bayer Aspirin tablets are newly approved as a thrombus prevention drug based on its antiplatelet effect.
 
It has also been approved for use in Kawasaki disease in infants and young children. It is used to suppress cardiovascular disorders associated with Kawasaki disease. In this case, the anti-inflammatory effect of high-dose aspirin is used to suppress inflammation of blood vessels and myocardium in the acute phase, and the antiplatelet effect of low-dose aspirin is used to suppress thrombus in the chronic phase.
 
This medicine is designed to dissolve in the intestines so as not to irritate the stomach. However, caution is still required regarding gastrointestinal disorders.


 
Efficacy
Aspirin acetylates COX1 (cyclooxygenase 1) in platelets, irreversibly inactivating its action.
It then inhibits the synthesis of TXA2 (thromboxane A2), which is involved in platelet aggregation, suppressing platelet aggregation. Due to this mechanism of action, it is technically known as a COX1 inhibitor.
 
○ Suppression of thrombosis and embolism formation in the following diseases
・Angina pectoris (chronic stable angina, unstable angina)
・Myocardial infarction
・Ischemic cerebrovascular disease (transient ischemic attack (TIA), cerebral infarction)
○ Suppression of thrombosis and embolism formation after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA)
○ Kawasaki disease (including cardiovascular sequelae of Kawasaki disease)

 
Usage
In general, for adults, take 1 tablet (100 mg of the active ingredient) at a time, once a day. The dosage may be increased up to 3 tablets (300 mg) at a time according to disease and symptoms of the patient. Strictly follow the instructions.
Unless instructed by your doctor, swallow the medicine as whole without chewing or cracking as it is an enteric coated tablet. Do not take on an empty stomach.
If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

 
Internal capacity
500 Tablets
 
＜Warning＞
Avoid drinking alcohol while taking this medicine as it may induce or increase gastrointestinal bleeding.
You have previously experienced allergic symptoms such as itching or rashes from medicine or food. You have a history of peptic ulcers, bleeding tendencies, or aspirin-induced asthma.
You are pregnant or breastfeeding.
You are using other medicines (they may strengthen or weaken each other's effects, so please be careful with other over-the-counter medicines and foods you are using).

 
The most commonly reported adverse reactions include gastrointestinal disorder, hives, rash, edema, anemia, platelet hypofunction (prolonged bleeding time), dizziness, headache, excitation, hyperpnea, malaise and hypoglycemia. If any of these symptoms occur, consult with your doctor or pharmacist.
 
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
 
respiratory distress, generalized flush, angioedema[shock, anaphylaxis]
headache, nausea/vomiting, blood vomiting/melena[intracranial/gastrointestinal bleeding]
fever, bloodshot eyes, facial and general redness[toxic epidermal necrolysis, mucocutaneous-ocular syndrome, exfoliative dermatitis]
bruise, nasal bleeding, high fever[aplastic anemia, thrombocytopenia, leukopenia]
breathing difficulty, wheezing[asthma attack]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

 
Ingredients 
Active ingredient per tablet: Aspirin 100mg
 
Additives: Corn starch, powdered cellulose, methacrylic acid copolymer LD, sodium lauryl sulfate, polysorbate 80, talc, hypromellose, triethyl citrate, carnauba wax, and 1 other ingredient.